Expression of DPC4 gene in esophageal carcinoma and its significance

Objective:To investigate the correlationship between the expressions of DPC4 and vascular endothelial growth factor(VEGF) in esophageal carcinoma and their clinicopathological behavior.Methods:The expressions of DPC4 and VEGF proteins were examined by immunohistochemical method in 174 cases of esophageal carcinoma tissues.Results:The positive rates of DPC4 in normal esophageal mucosa.and esophageal carcinoma were 80% and 40.8%,respectively(P0.005).The expression of DPC4 was higher in adenocarcinomas than in squamous carcinomas(P0.05).With the depression of differentiation,the positive rate of DPC4 descended,but was not significant(P0.05).The DPC4 expression of the group with lymph node metastasis was lower than the group without that(P0.005).But the positive rates of VEGF in normal esophageal mucosa.and esophageal carcinoma were 23.3% and 43.1%,respectively(P0.005).With the depression of differentiation,the positive rate of VEGF ascend.The VEGF expression of the group with lymph node metastasis was higher than the group without that(P0.05).The expression of DPC4 was nagtive correlated with the expression of VEGF(P0.001).Conclusions:The low expression of DPC4 is an important factor of esophageal carcinoma occurrence;The low expression of DPC4 may accelerate creating blood vessels and lymph node metastasis of esophageal carcinoma.