Effects of transient intensive insulin treatment on the related indices of newly diagnosed T2DM patients

Objective To study the effect of transient intensive insulin treatment on the related indices of newly diagnosed T2DM patients.Methods Sixty-four newly diagnosed T2DM patients were divided into two groups and treated by transient intensive insulin treatment in the way of multiple subcutaneous insulin infusion(MSII) and continuous subcutaneous insulin infusion(CSII).The FPG,2 hPG,TC,TG,LDL-C,HDL-C,FFA,C-RP,arginine stimulation test(Ins 0,2,4,6 minute),HOMA-β,and HOMA-IR were determined before and after treatment for comparison.Results After treatment in both groups the levels of FPG,2 hPG,TC,TG,LDL-C,FFA,C-RP,and HOMA-IR were decreased significantly(P0.05),and the levels of HOMA-β and Ins2+4+6 were increased significantly(P0.05).There was no significant difference between the two groups(P0.05).Pearson correlation analysis showed that the increase of HOMA-β and Ins2+4+6 was positively correlated with the decrease of FPG and FFA(P0.05).The multiple regression analysis showed that BMI was an independent related factor affecting HOMA-β and Ins2+4+6(P=0.000).Conclusion The transient intensive insulin treatment can evidently improve β-cell functions and relieve insulin resistance in newly diagnosed T2DM patients.The improvement of islet β-cell function is related to the improvement of glucose metabolism,lipid metabolism,and bodyweight.