Clinical significance of determination of β_2-microglobulin in patients with multiple myeloma.

Objective To analyze the clinical significance of determination of β2-MG in patients with multiple myeloma. Methods β2-MG in serum and urine of 40 multiple myeloma patients was determined by micro particle enzyme immunoassay. Meanwhile erythrocyte sedimentation rate, hemoglobin, creatinine, calcium were also determined. Results The levels of β2-MG in serum and urine of patients with multiple myeloma patients before treatment were significantly higher than those in control(P0.01). The levels of β2-MG in serum and urine of patients in group I,Ⅱand Ⅲ after treatment were significantly lower than those before treatment(P0.01). Conclusion The level of β2-MG is closely associated with the occurrence and development of multiple myeloma and it is valuable for the classification and the judgment of therapeutic effect.