Clinical value of determination of β2-MG and CRP levels in patients with multiple myeloma

Objective To study the clinical significance of determination of plasma levels ofβ2-MG and CRP in patients with multiple myeloma(MM).Methods Plasma levels of TNF-α and β2-m were determined in 42 patients with multiple myeloma before and after chemotherapy,and it also been determined in 50 healthy controls.Results The plasma levels of β2-MG and CRP in patients with multiple myeloma were significantly higher than those controls(P 0.01).The plasma levels of β2-MG and CRP were decreases after the chemotherapy.And there had a long surval time in patients with a lower plasma levels of β2-MG and CRP than those with a higher level.Conclusion The determination of plasma levels ofβ2-MG and CRP might be helpful for diagnosis,curative effect monitoring and prognosis in patients with multiple myeloma.