DETECTION AND CLINICAL SIGNIFICANCE OF BLOOD HOMOCYSTEINE、β_2 -MICROGLOBULIN AND ERYTHROCYTE SEDIMENTATION RATE IN MULTIPLE MYELOMA

Objective:To measure the levels of blood homocysteine、β2-microglobulin and erythrocyte sedimentation rate in different phrases of patients with multiple myeloma,and to explore their significance in the diagnosis and clinical therapy of multiple myeloma.Methods:The β2-MG、 ESR and Hcy of 30 multiple myeloma patients and 20 health adult were detected,the results were analyzed in different phrases.Results:(1)Compared with normal control group,blood levels of β2-MG、 ESR and Hcy were elevated before treatment in multiple myeloma patients(P0.05、P0.05 and P0.01).(2)The factors of patients with MM at different stages were statistially significant(P0.05 and P0.01).(3)Compared with normal control group,the β2-MG、 ESR and Hcy had no difference in multiple myeloma after complete remission(CR)(P0.05).(4)Compared with MM patients before treatment,β2-MG、 ESR and Hcy had also no difference in multiple myeloma after non-remission(NR)(P0.05).(5)There was positive correlation between Hcy and β2-MG、 ESR in multiple myeloma[(r=0.71,P0.01) and(r=0.45,P0.05)].Conclusion:Therefore,monitoring in different prase the content of blood β2-MG、 ESR and Hcy in multiple myeloma provided the evidence in theory for early diagnosis prevention and cure of multiple myeloma in clinic.