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Clinical significance of β_2-MG and LDH measurement in patients with multiple myeloma

Zhao Xiao-hong

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Abstract

Objective To investigate the clinical significance of the serumβ2-microglobulin (β_2-MG) and lactic dehydrogenase (LDH) measurment in patients with multiple myeloma.Methods 36 patients with multiple myeloma were enrolled in this study. β_2-MG and LDH were measured by rate method and radioimmunoassay, respectively.Results Patients were classified into phase I or phase II or phase III,group A or group B, responsive to or unresponsive to chemotherapy group for comparison purose.It was found that value of β_2-MG and LDH for patients in the later categories were significantly higher than those in the former categories(e.g. phaseⅡ phaseⅠ, phaseⅢ phase II) (P0.05). The differences before and after chemotherapy for unresponsive to chemotherapy group were not significant(P0.05).Conclusion Serum level of β_2-MG and LDH can be used as an auxiliary clinical index for the determination of disease phases, prognosis and treatment effectiveness in patients with multiple myeloma.

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What this paper is about

Objective To investigate the clinical significance of the serumβ2-microglobulin (β_2-MG) and lactic dehydrogenase (LDH) measurment in patients with multiple myeloma.Methods 36 patients with multiple myeloma were enrolled in this study. β_2-MG and LDH were measured by rate method and radioimmunoassay, respectively.Results Patients were classified into phase I or phase II or phase III,group A or group B, responsive to or unresponsive to chemotherapy group for comparison purose.It was found that value of β_2-MG and LDH for patients in the later categories were significantly higher than those in the former categories(e.g. phaseⅡ phaseⅠ, phaseⅢ phase II) (P0.05). The differences before and after chemotherapy for unresponsive to chemotherapy group were not significant(P0.05).Conclusion Serum level of β_2-MG and LDH can be used as an auxiliary clinical index for the determination of disease phases, prognosis and treatment effectiveness in patients with multiple myeloma.

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Available abstract

Objective To investigate the clinical significance of the serumβ2-microglobulin (β_2-MG) and lactic dehydrogenase (LDH) measurment in patients with multiple myeloma.Methods 36 patients with multiple myeloma were enrolled in this study. β_2-MG and LDH were measured by rate method and radioimmunoassay, respectively.Results Patients were classified into phase I or phase II or phase III,group A or group B, responsive to or unresponsive to chemotherapy group for comparison purose.It was found that value of β_2-MG and LDH for patients in the later categories were significantly higher than those in the former categories(e.g. phaseⅡ phaseⅠ, phaseⅢ phase II) (P0.05). The differences before and after chemotherapy for unresponsive to chemotherapy group were not significant(P0.05).Conclusion Serum level of β_2-MG and LDH can be used as an auxiliary clinical index for the determination of disease phases, prognosis and treatment effectiveness in patients with multiple myeloma.

Key concepts: Medicine, Multiple myeloma, Beta-2 microglobulin, Internal medicine, Chemotherapy, Gastroenterology, Clinical significance, Radioimmunoassay

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