Ribavirin combined with dioctahedral-smectite in treatment of rotavirus enteritis

Objective:To analyze the curative effect of ribavirin combined with dioctahedral-smectite(smecta,DS) on ro-tavirus enteritis. Methods:Totally 168 children with rotavirus enteritis, aged from 6 month to 2 years, were randomly divided into 4 groups (3 treatment groups and a control group). All cases were treated with liquid infusion and other supportive treatment. Group A(n = 41) was treated with ribavirin intravenous injection, group B(n = 40) was treated with DS orally, and group C(n = 45) was treated with ribavirin and DS. The effective rate, symptom amelioration time, average hospital stay and side effects were analyzed. Results:Compared with control group,3 treatment groups had higher effective rate and shorter average hospital stay and symptom amelioration time(P0. 05). The average hospital stay and the time of heat retreating of group C were shorter than those of group A and B(P0. 05). There was not significant difference about the effective rate between group B and A. No obvious side effect was observed in all groups. Conclusion:Combinative administration of ribavirin and DS is an effective and safe therapeutical scheme for rotavirus enteritis.