Plasma adiponectin level and its correlation in patients with essential hypertension of Kazakans

Objective To explore the plasma adiponectin(APN)levels in the patients with essential hypertension(EH) of Xinjiang Kazakans and the relations between plasma adiponectin level and insulin resistance(IR),blood glucose,blood lipids,blood pressure and obesity.Methods Totally 127 Kazakans EH cases were selected for the subjects.They were divided into two groups according to their blood pressure: EH group(n=67) and control group(n=60).Measurment of blood pressure,body height,body mass,waist circumference(WC) and hip.Fasting venous blood was drawn to detect the plasma APN,fasting insulin(FINS),fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apoprotein-A1(ApoA1) and apoprotein-B(Apo-B),calculating body mass index(BMI),waist-hip ratio(WHR),body fat percentage(BF%) and homeostasis model assessment of insulin resistance index(HOMA-IR).Results ①The plasma adiponectin concentration in EH group was significantly lower than that in control group(P0.01).②APN was negatively and significantly correlated with systolic blood pressure(SBP),diastolic pressure(DBP),WC,BMI,WHR,FPG,FINS,HOMA-IR,TG,LDL-C,Apo-B in EH group.and negatively and significantly correlated with SBP,DBP,WC,BMI,WHR,FINS,HOMA-IR in control group.③Multiple regression analysis showed that HOMA-IR and WC were independent factors to affect the APN level in EH group,FINS and BMI were independent factors to affect the plasma adiponectin level in control group.Conclusions Concentration is decreased in the patients with EH of Kazakans,and there is correlation between APN and blood pressure.