Relationship of serum adiponectin and insulin resistance in patients with essential hypertension

Objective To observe the levels of serum adiponectin in patients with essential hypertension,and the relationships between adiponectin and blood pressure(BP),insulin resistance.Methods Sixty-five patients with essential hypertension and forty normotensive healthy subjects were studied.Fasting plasma adiponectin was assayed by ELISA technique,and related parameters such as BP,body mass index(BMI),waist circumference(WC),fasting blood glucose,and insulin were measured.According to the typical HOMA model,insulin resistance index(HOMA-IR)and insulin sensitivity index(ISI)were calculated.Results The level of serum adiponectin was significantly lower in essential hypertension group than that in normotensive healthy subjects [(10.30±0.93)μg/ml vs(12.83±1.66)μg/ml,P=0.000].Plasma adiponectin in essential hypertension group was negatively related to systolic blood pressure(SBP,r=-0.304,P=0.032),BMI(r=-0.496,P=0.000),WC(r=-0.539,P=0.000),fasting insulin(r=-0.291,P=0.040),HOMA-IR(r=-0.334,P=0.018),while positively to ISI(r=0.297,P=0.037).Multiple regression analysis showed that SBP and WC were the independent risk factors of serum adiponectin in patients with essential hypertension.Conclusion The serum adiponectin was significant lower in patients with essential hypertension,and there were significant negative correlations between adiponectin and systolic blood pressure and insulin resistance.