Protective effect of Zn-pipemidate on experimental gastric ulcer and its mechanism

AIM: To study protective effest of Zn-pipemidate on experimental gastric ulcer and its mechanism. METHODS: Pylous-ligated, stess-induced, acetic acid-induced and reserpine-induced gastric ulcers in rats or mice were used in experiment. Rats or mice were randomly divided into five groups including carboxymethylcellulose (CMC), cimetidine and three doses of Zn-pipemidate ( 0.025, 0.05, 0.1 g·kg -1). The drugs were given ig, once a day, for 5d. Gastric juice, out-put of pan-acid, pepsin activity and the volume of mucus gastric wall were determined in pylorus-ligated gastric ulcer in rats. RESULTS: Zn-pipemidate could inhibited the formation of all gastric ulcer models in a dose-dependent manner. All of the three doses of Zn-pipemidate groups could reduce out-put of pan-acid (P 0.01) and pepsin activity, and increase the volume of mucus gastric wall (P 0.01). CONCLUSION: Zn-pipemidate can protect experimental gastric ulcer. Its mechanism is related to increasing protective factors and reducing damaging factors of gastric mucosa.