Serum C-reactive protein levels in elder patients with coronary heart disease and effect of aspirin intervention

Objective To investigate the serum C-reactive protein(CRP) concentrations in elder patients with coronary heart disease(CHD) and the change of serum CRP concentrations in patients with CHD treated with aspirin.Methods Ninety elder patients with CHD were administered aspirin at the dose of 100mg/d(CHD1 group),150mg/d(CHD2 group),200mg/d(CHD3 group).Normal subjects were selected as control(control group),there were thirty subjects in each group.The detected parameters included serum CRP concentrations for 0 and 12 weeks.Results CRP concentration in patients with coronary heart disease was significantly higher than that of the normal subjects(P0.05).CRP concentration in patients with CHD could reduce with aspirin 150mg/d,200mg/d for 12 weeks(P0.05).Conclusion The serum CRP concentration is associated with patients with CHD,the serum CRP concentration could reduced with bigger dosage of aspirin.The occurance and development of CHD is correlative to inflammation,aspirin could dose-dependantly attenuate the progression of CHD.