Effect of salidroside on ischemia in acute necrotizing pancreatitis

Objective To observe the effect of salidroside on ischemia in rats with acute necrotizing pancreatitis(ANP) model and discuss the mechanism.Methods Two hundred Wistar rats were divided into three groups randomly:sham operation group(n =50) control group(n =75) and experiment group(n =75).Rats in control group and experiment group were made to acute necrotic pancreatitis model by artery blocking and the sham operation group were treated by abdominal incision,and the rats in experiment group were treated with salidroside i.v.Blood sample was drawn at 0,2nd,4th,8th,12 th h after reperfusion,and the levels of blood amylase,TXB_2,IL-8 were detected.Results At the 4th h,blood amylase began to decrease in experiment group,compared with control group at the8 th and 12 th h,the differences were significant(P 0.05);At 8th h and 12 th h,TXB_2 in experiment group was significantly lower than that in control group(P 0.05);TXB-2 in control group increased at 12 th h and TXB_2 in experimental group began to decrease at 4th h,compared with control group,the difference was significant at the 8th h(P 0.05);IL-8 in control group increased in 12 h and IL-8 began to decrease at 12 th h,compared with control group IL-8 decreased significantly at the 12 th h(P 0.05).Conclusion Salidroside could protect ischemia injury in rats with ANP and decrease the levels of amylase,TXB_2 and IL-8.