Experimental research on the curative effect on chronic renal failure rats' damage of renal function and brain tissue with Yinshen Jiangdan Decoction

Objective:To discuss the Yishen Jiangdan decoction's effect on prevention and treatment of chronic renal failure and Uremic encephathy.Method:Using purine to make the CRF rat model, giving Yinshen Jiangdan decoction to experimental group, and giving water to control group. Observing index changes of BUN, SCr, UUN, UCr, UPr before and after treatment of rats in all groups and the pathologic changes of rats'brain tissues under light microscope. Results: This decoction could slow down the progress of experimental rats′renal failure, improve the creatinine clearance rate, decrease the blood serum BUN、SCr consistency. Its effect on decreasing SCr was much better than that of BUN. At same time it had an obviously protective effect on brain tissues. Experimental group's brain tissues, brain cells, gyrus hippocampi had less damaged than that of control group.Conclusion:Yinshen Jiangdan decoction has obviously protective effect on CRT rats' brain tissues. Prompt that use vasoactive drugs in the treatment of CRF patients can have an active effect on slow down UE, ET's happen.