2010•China Medical HeraldRequires access

Study on the expression about the receptors of ER,PR and IGF-1R in the uterine neoplasms

Xiu-zhi Zhao

Abstract

Objective:To research the variety of the insulin-like growth factor 1 receptor(IGF-1R) in human uterine neoplasms and the normal cell of uterine smooth muscle cells around and its relationship to receptors of estrogen,proges terone.Methods:The expressions of estrogen receptor(ER),progesterone receptor(PR) and insulin-like growth factor 1 receptor(IGF-1R) were detected by immunohistochemical SABC methods,and its image analysis was also conducted.Results:The expression of ER,PR,IGF-1R in uterine leiomyoma cells was significantly higher than the myometrial cells.Conclusion:The growth of uterine leiomyoma is associated with the reinforcement of the expression of ER,PR and IGF1R.

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Key concepts: Medicine, Receptor, Estrogen receptor, Immunohistochemistry, Insulin-like growth factor 1 receptor, Uterine leiomyoma, Smooth muscle, Insulin-like growth factor