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Studies on Preparation and Permeation though Excised Rat's Skin of Huanglianjiedu Cataplasm

Liu Yue-yua

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Abstract

L9(3 4) Orthogonal design was used to select the optimum formula of bases of Huanglianjiedu cataplasm. Results showed the optimum formula of bases was A 1B 2C 2 or acacia gum: gelatin: glycerol=1∶0 1∶2, and the content of extractive was 30%. Then skin permeation and enhancing effect of azone of Huanglianjiedu Cataplasm were investigated in an improved Francz diffusion cell according to the content of berberine. Results showed berberine could permeate through rat skin slowly; The permeation rates and the cumulative permeation amount of berberine was improved markedly with 1% azone and very markedly with 3% and 5% azone.

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What this paper is about

L9(3 4) Orthogonal design was used to select the optimum formula of bases of Huanglianjiedu cataplasm. Results showed the optimum formula of bases was A 1B 2C 2 or acacia gum: gelatin: glycerol=1∶0 1∶2, and the content of extractive was 30%. Then skin permeation and enhancing effect of azone of Huanglianjiedu Cataplasm were investigated in an improved Francz diffusion cell according to the content of berberine. Results showed berberine could permeate through rat skin slowly; The permeation rates and the cumulative permeation amount of berberine was improved markedly with 1% azone and very markedly with 3% and 5% azone.

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Available abstract

L9(3 4) Orthogonal design was used to select the optimum formula of bases of Huanglianjiedu cataplasm. Results showed the optimum formula of bases was A 1B 2C 2 or acacia gum: gelatin: glycerol=1∶0 1∶2, and the content of extractive was 30%. Then skin permeation and enhancing effect of azone of Huanglianjiedu Cataplasm were investigated in an improved Francz diffusion cell according to the content of berberine. Results showed berberine could permeate through rat skin slowly; The permeation rates and the cumulative permeation amount of berberine was improved markedly with 1% azone and very markedly with 3% and 5% azone.

Key concepts: Azone, Permeation, Chemistry, Berberine, Chromatography, Gelatin, Membrane, Organic chemistry

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