Study on Transdermal Absorption of Indometacin Cataplasm in Vitro

Objective:To study the transdermal characteristics of indomethacin cataplasm containing azone 、indomethacin cataplasm with no azone and commercially available cream in vitro.Methods: Using rat skin penetration test in vitro with modified Franz diffusion cell,the concentration of indomethacin was determined by HPLC method.The cumulative penetration amount and penetrating rates of indomethacin were calculated.Results: The cumulative penetration amount of indomathacin was linearly related to time ,penetrating rates of these three preparations were 71.3,47.8 and 50.7 μg·cm-2·h-1 respectively .The penetrating rates of cataplasm containing azone were increased significantly than the cataplasm with no azone or the cream(the value of q were 7.619 6,6.678 0 respectively,P 0.01).There were no significant difference in the penetrating rates between the cataplasm with no azone and the cream(q = 0.941 6,P 0.05).Conclusions:The indomethacin cataplasm containing azone has better penetrating rate,which has applicating value.