The effect of permeation enhancers on increasing transdermal permeation of compound hyperosteogeny patch

OBJECTIVE To probe the influence of the two kinds of permeation enhancers, azone and lepaloine on transdermal permeation of Compound hyperosteogeny patch(CHP). METHODS Patches containing azone and lepaloine at different concentrations were prepared,and the role of enhancing permeation of azone and lepaloine for the main active component , ferulic acid were studied by in vitro permeation experiments. RESULTS Both Azone and Lepaloine at different concentrations have the role of enhancing permeation. In the experiments azone is better than Lepaloine and the best concentration of azone is 3% . The permeation enhancing multiple of 3% Azone group is the highest which is 8.1.CONCLUSION With the cumulative permeation quantity of ferulic acid as the index, 3% azone is more suitable to act as a permeation enhamer of CHP.