Inhibition Effect of Resveratrol on the Myelonic Neuronal Apoptosis in Rats with Spinal Cord Injury

Objective:To investigate the changes on the myelonic neuronal apoptosis in the rats fed with resveratrol after spinal cord injury.Methods:A total of 96 adult male Sprague-Dawley rats were randomly divided into four groups as sham-operation group,spinal cord injury model group,resveratrol treatment group,and methylprednisolone treatment group.After the model of moderate spinal cord injury was established according to the Allen's technique,resveratrol(100mg/kg)or methylprednisolone was immediately fed.The changes of the myelonic apoptotic masculine neuronal number were observed by TUNEL method on the resveratrol group and the injury group at the time of 8 hours,1 day,3 days and 7 days after spinal cord injury.Results:The apoptotic neuronal number between resveratrol treatment group and injury group was significant different(P0.01)at all time-points during observation.No statistical difference was found between resveratrol group and methylprednisolone treatment group(P0.05)at all time-points except on the 1st day(P0.05).Conclusion:Resveratrol can restrain the neuronal apoptosis and exert the protection on the neuronal cells after spinal cord injury.