Effect of Resveratrol on Motor Function and Cells Apoptosis after Acute Spinal Cord Injury in Rats

To investigate the effect of resveratrol(Res) on motor function,histopathology and neuronal cells apoptosis after spinal cord injury in rats.Methods: 24 SD rats were randomly divided into 3 groups.A group:sham-operation group;B group :spinal cord injury group;C group Res group.Animal model of acute spinal cord was induced through Allen's method.In RES group,At last,the hindlimb motor function in the spinal cord were observed at the 24,48 and 72 h after modeling.The samples were taken from the spinal cord injury sites at 72 hours after the injury and tested by HE、Nissl staining for histopathological a and by TUNEL method for cell apoptosis.Results:The hindlimb motor function of C group and B group became better at the 24hours,48 hours,72 hours,and there was obvious difference(P0.05);Histopathological observation showed that tissue damage to the structure of C group significantly lighter than B group;The apoptotic cells positive of TUNEL were detectable in both three experimental groups.In the C group,the number of apoptotic cells was less and neuronal function of the spinal cord better as compared with those in the B group.Conclusion: Res significantly to spinal cord injury in rats after hindlimb motor function recovery of the nerve to protect the neural structure of nerve cell damage and inhibition of apoptosis.