Clinical Study of Sufentanil in Postoperative Patient-controlled Epidural Analgesia for Patients with Chest Tumors

Objective To compare the clinical effect and safety of different concentration of sufentanil combined with bupivacaine for patient-controlled epidural analgesia(PCEA) after thoracic operation.Methods Sixty patients(ASA Ⅰ-Ⅲ) undergone thoracic surgery were assigned at random and double-blind method to four groups for receiving PCEA with sufentanil 0.25 μg/ml(groupⅠ,n=15), sufentanil 0.50μg/ml(group Ⅱ,n=15), sufentanil 0.75 μg/ml(group Ⅲ,n=15)and fentanyl 5 μg/ml(groupⅣ,n=15). In each group, the concentration of bupivacaine was 0.188%, and 100ml analgesia fluid included droperidol 5mg. Visual analogue scales(VAS), visual analogue fatigue scales (VAFS), Ramsay scales and side-effects including pruritus, nausea and emesis were assessed after the 4th,8th,12th,24th and 48th hour of postoperative analgesia.Results After the 48th hour of postoperative analgesia, VAS and VAFS scores both in group Ⅱ and group Ⅲ were lower than that in groupⅠ(p0.05 or p0.01).VAS and VAFS in group Ⅲ were lower than that in group Ⅱ (p0.05). In groupⅠ,the Ramsay scores at the 8th to the 24th hour after operation were lower than that in the other groups (p0.05). Conclusion Sufentanil combined with lower concentration bupivacaine is suitable for PCEA after thoracic operation,and the dose of sufentanil 0.75ug/ml can obtain a better postoperative analgesia.