Clinical Application of Sufentanil in Postoperative Patient-controlled Intravenous Analgesia for Patients with Upper Abdominal Surgery

Objective To compare the clinical effect and safety of different concentration of sufentanil for patient-controlled intravenous analgesia(PCIA) after upper abdominal surgery.Methods Ninety patients undergoing upper abdominal surgery were assigned with random and double-blind method to three groups for receiving PCIA with sufentanil 1.5μg/ml(group A,n=30),sufentanil 1.0μg/ml(group B,n=30) and fentanyl 10 μg/ml(group C,n=30).Visual analogue scales(VAS),sedation,side-effects including nausea and emesis,SPO2,respiration rate and pressure times were assessed after the 4th,8th,12th,20th and 48th hour of postoperative analgesia.Results After 48h of postoperative analgesia,VAS scores in group A were lower than that in group B and C(p0.05).VAS scores in group B and C were equivalent(p0.05).Conclusions Sufentanil is suitable for PCIA after upper abdominal surgery,the side-effects is small and the dose of sufentanil 1.5ug/ml can obtained a better postoperative analgesia.