DIFFERENT CONCENTRATION OF SUFENTANIL AND FENTANYL FOR POSTOPERATIVE PATIENT-CONTROLLED INDUCE ANALGESIA AFTER THORACIC OPERATZON A RANDOMIZED,DOUBLE-BLIND COMPARISON

Objective: To compare the clinic effect and safety of different concentration of sufentanil and fentanyl for postoperative patient-controlled induce analgesia after thoracic operation.Methods: Forty-five patients undergoing thoracic surgery were assigned to groups receiving patient-controlled induce analgesia(PCIA) with fentanyl 10 μg/ml(A,n=15),sufentanil 1 μg/ml(B,n=15),sufentanil 1.25 μg/ml(B,n=15).Visual analogue scale(VAS),VAFS,satisfaction,sedation scores at rest and on movement,vital signs(MAP,HR,RR,SpO_2)and side-effects including nausea,emesis,pruritus and resperitory inhibition were assessed after 6,12,24 and 48 h of postoperative analgesia.Results: After 48h of postoperative analgesia,VAS scores were higher in group B than group A and group C(P0.05 or P0.01).After 12 h of postoperative analgesia,VAS scores were higher in group B than group A and group C(P0.01),After 24 h of postoperative analgesia,VAS scores were higher in group B than group C(P0.01).After 12 h of postoperative analgesia,VAFS scores were higher in group B than group C and group A(P0.05 or P0.01).The scores of satisfaction of postoperative analgesia were lower in group B than group C and group A(P0.05 or P0.01).The incidence of adverse events including side-effects(nausea,emesis,pruritus and resperitory inhibition) is lower.Conclusion: Sufentanil 1.25 μg/ml and fentanyl 10 μg/ml provide the same analgesia effect.