Study on the Optimization of the Preparation Technology of Radix isatidis Dropping Pills

[Objective] The research aimed to study the effects of various influencing factors of Radix isatidis dropping pills and establish the best preparation technology.[Method] Using appearance quality,disintegration time limit and weight difference of pills as evaluation indices,various influencing factors were investigated by using orthogonal test.[Result] PEG6000:PEG4000 of 9:1 was used as substrate,the ratio of drug to matrix was 1:3,temperature of mixture was 80 ℃,dimethylsilicone oil was used as condensing agent,the temperature of coolant was 5 ℃,dropping speed was 50 drop/min and drop distance was 7 cm.The prepared dropping pills had good appearance quality,short disintegration time limit and small weight difference of pills.The hygroscopicity was smaller than that of granules.[Conclusion] The prepared dropping pills had stable quality,good reproducibility and simple device.And they were suitable for the industrialization production.