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2012•Inner Mongolia Medical JournalRequires access

E-Cad and COX-2 Expression and Gastric Cancer Tissue Biological Behavior

Weishi Gao

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Abstract

Objective:To investigate the expression of COX-2 and E-cad in gastric carcinoma and explore their relationship and clinical significance.Methods:The expression of COX-2 and E-cad was detected by immunohistochemistry in 62 gastric cancer specimens collected after operations and 20 cases of normal gastric mucosa as control.Results:The expression rates of E-cad in gastric cancer tissues was 28.3%,high expression in normal gastric mucosa tissue(P0.01),but the expression rates of COX-2 in gastric cancer tissues was 68.3%.lower positive expression in normal gastric mucosa tissue(P0.01).There was a significant negative correlation between COX-2 and E-cad expressionin gastric cancer,as the expression of E-cad lower,the expression of COX-2 increased.Conclusions:The overexpression of COX-2 and E-cad in gastric carcinoma enhances the possibility of invasion and metastasis and could be one of the signs of the poor prognosis.

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Objective:To investigate the expression of COX-2 and E-cad in gastric carcinoma and explore their relationship and clinical significance.Methods:The expression of COX-2 and E-cad was detected by immunohistochemistry in 62 gastric cancer specimens collected after operations and 20 cases of normal gastric mucosa as control.Results:The expression rates of E-cad in gastric cancer tissues was 28.3%,high expression in normal gastric mucosa tissue(P0.01),but the expression rates of COX-2 in gastric cancer tissues was 68.3%.lower positive expression in normal gastric mucosa tissue(P0.01).There was a significant negative correlation between COX-2 and E-cad expressionin gastric cancer,as the expression of E-cad lower,the expression of COX-2 increased.Conclusions:The overexpression of COX-2 and E-cad in gastric carcinoma enhances the possibility of invasion and metastasis and could be one of the signs of the poor prognosis.

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Available abstract

Objective:To investigate the expression of COX-2 and E-cad in gastric carcinoma and explore their relationship and clinical significance.Methods:The expression of COX-2 and E-cad was detected by immunohistochemistry in 62 gastric cancer specimens collected after operations and 20 cases of normal gastric mucosa as control.Results:The expression rates of E-cad in gastric cancer tissues was 28.3%,high expression in normal gastric mucosa tissue(P0.01),but the expression rates of COX-2 in gastric cancer tissues was 68.3%.lower positive expression in normal gastric mucosa tissue(P0.01).There was a significant negative correlation between COX-2 and E-cad expressionin gastric cancer,as the expression of E-cad lower,the expression of COX-2 increased.Conclusions:The overexpression of COX-2 and E-cad in gastric carcinoma enhances the possibility of invasion and metastasis and could be one of the signs of the poor prognosis.

Key concepts: Medicine, Cancer, Immunohistochemistry, Gastric mucosa, Pathology, Clinical significance, Metastasis, Gastric carcinoma

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