2000•Chinese Journal of Integrated Traditional and Western NephrologyRequires access
The Study on Influence of JianShenHeJi Decoction to Calcium and Phosphorus in Blood and Urine of Chronic Renal Failure Rats Induced by Adenine Influenced
Li Ma
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Abstract
Objective:To study the variety law of calcium and phosphorus in blood of chronic renal failure rats; To discuss JianShenHeJi's partial mechanism of ameliorating the low - calcium - high - phosphorus state. Methods: The animal models of CRF were created by pouring Adenine to Wistar rats for twenty days (250 mg·kg-1·d-1) ; We treated them by pouring JianShenHeJi decoction (2 ml/d) for thirty days, compared with NiaoDuQing decoction. Blood Scr, twenty - four hours urinary protein, blood CT, PTH, calcium and phosphorus were detected by different means. Results : The contents of blood calcium and PTH in CRF rats were notably down While the contents of blood phosphorus and CT were obviously up (P 0. 05 - 0. 01); In ameliorating BUN, Scr, PTH and twenty - four hours urinary protein, JianShenHeJi decoction's effect are approximated to NiaoDuQing decoction with no notable significance (P0.05);In ameliorating blood calcium, phosphorus and CT, JianShenHeJi decoction are better than NiaoDuQing decoction(P0.05-0.01) . Conclusion;JianShenHeJi decoction can amend CRF'S low- calcium- high - phosphorus state, and has the better effect than NiaoDuQing decoction. That may by one of its action mechanism of curing CRF.