Expression of Survivin in Lung Cancer and Its Significance

Objective:To invegtigate the expression of survivin in non-small cell lung cancer and its relationship to clinicopathological features.Methods: The expression of survivin was detected by immunohistochemical SP technique in cancerous tissue and paraneoplastic tissue in 30 cases of lung cancer.Results: The positive rate of expression of survivin was 76.7% in lung cancer,O in Paraneoplastic tissue.The positive expression of survivin in lung cancer was not related to sex,age,Smoking,size of tumor,typing and grading,lymphnode metastasis and TNM stages.Conclusion: The abnormal expressed survivin gene may play an important role in the genesis and development of lung cancer and offer new target to early digsnosis and gene therapy.