Protection of Longjia Xuemaitong Capslue on myocardial ischemia and myocardial ischemia-reperfusion injury in rats

Objective To observe protective effects of Longjia Xuemaitong Capslue on myocardial ischemia and cardiac reperfusion injury.Methods Using the myocardial ischemia model of rats induced by pituitrin and isoproterenol,the effects of Longjia Xuemaitong Capslue on myocardial ischemia were investigated.Moreover,using the myocardial ischemia-eperfusion injury model of rats induced by operation,the protective effects of Longjia Xuemaitong Capslue on myocardial ischemia-reperfusion injury were observed.Results At the doses of 1.60,0.80,0.40 g/kg,Longjia Xuemaitong Capslue could significantly reduce the T wave height at 15 and 30 s in the ischemia rats induced by pituitrin as well as the offset height of S-T segment at 5,10,20,and 30 min in ischemia rats induced by isoproterenol.Longjia Xuemaitong Capslue at the doses of 1.60,0.80,and 0.40g/kg could significantly decrease the malondialdehyde (MDA) level in serum,increase the superoxide dismutase (SOD) level,and obviously decrease the percentage that the infarct area accounted for the ischemic area in the myocardial ischemia-reperfusion injury of rats.Conclusion Longjia Xuemaitong Capslue could protect the myocardial ischemia and myocardial ischemia-reperfusion injury.