2008•Shiyong kouqiang yixue zazhiRequires access

Expression of CLC-7 during mouse tooth development

WU Li-a

Abstract

Objective: To determine the expression and distribution of CLC-7 during the mouse tooth development and explore the possible function of CLC-7 in tooth formation. Methods:RT-PCR and immunofluorescence methods were used to investigate mRNA and protein expression of ClC-7 in the mouse tooth germ. Results:Clcn7 mRNA was observed in the tooth germ of new born mouse. Immunostaining showed that CLC-7 located in outer enamel epithelium cells, inner enamel epithelium cells, stellate reticulum cells, stratum intermedium cells, dental papillary cells, ameloblasts and odontoblasts in E18 tooth germ(bell stage). Conclusion:CLC-7 has a spatial and temporal distribution during mouse tooth development and might contribute to the mouse tooth development.

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Key concepts: Ameloblast, Odontoblast, Dental papilla, Immunostaining, Cell biology, Epithelium, Biology, Enamel organ