2014•Beijing Journal of StomatologyRequires access
Expression of Notch1 in developing mouse mandibular incisor tooth germ
Wang Xue-ji
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Abstract
Objective To investigate the expression of Notch1 in developing mouse mandibular incisor tooth germ. Methods Cryosections of developing ICR mouse mandibular incisor tooth germ in different developmental stages were prepared. The expression of Notch1 in the tooth germ tissue was examined by immunohistochemistry. Results Notch1was not expressed in the tooth germ epithelium which adjoined the neighboring mesenchyme but expressed in the upper oral epithelia. From cap to bell stage of the tooth germ,Notch1 was expressed in stratum intermedium but not in inner enamel epithelia. In addition,Notch1 was also expressed in the stellate reticulum and some undifferentiated tooth epithelial cells of the cervical loop. Besides,Notoch1 was expressed in the mesenchyme,dental papillae and early dental pulp. Conclusion Notch1 may play an important role in the dental epithelial cell,especially in the inner enamel epithelial cell differentiation during the mouse mandibular incisor tooth development and may also be needed in dental follicle,dental papillae and dental pulp cell development and homeostasis.