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Expression and localization of P75NGFR during mouse tooth germ development

Lingying Wen

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Abstract

AIM:To investigate the expression and localization of P75NGFR during mouse tooth germ development.METHODS:Immunohistochemical staining and image analysis technique were used to observe and analyze the expression of P75NGFR during mouse tooth germ development.RESULTS:P75NGFR was expressed at all stages of mouse tooth germ development with different degrees.The expression of P75NGFR was positive in oral epithelium and enamel organ epithelial cells at bud stage.P75NGFR was expressed positively in oral epithelium and stellate reticulum of cap stage and bell stage(E14 d～P1 d).During postnatal 2~10d(crown development stage);P75NGFR was found positive in ameloblast,odontoblast,predentin,dental papilla cells and dental sac cells.During P10~30d(tooth root development stage),P75NGFR was strongly positive in epithelial root sheath and alveolar bone besides those mentioned above.CONCLUSION:P75NGFR participates in the developmental process of tooth germ and tooth tissues.

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What this paper is about

AIM:To investigate the expression and localization of P75NGFR during mouse tooth germ development.METHODS:Immunohistochemical staining and image analysis technique were used to observe and analyze the expression of P75NGFR during mouse tooth germ development.RESULTS:P75NGFR was expressed at all stages of mouse tooth germ development with different degrees.The expression of P75NGFR was positive in oral epithelium and enamel organ epithelial cells at bud stage.P75NGFR was expressed positively in oral epithelium and stellate reticulum of cap stage and bell stage(E14 d～P1 d).During postnatal 2~10d(crown development stage);P75NGFR was found positive in ameloblast,odontoblast,predentin,dental papilla cells and dental sac cells.During P10~30d(tooth root development stage),P75NGFR was strongly positive in epithelial root sheath and alveolar bone besides those mentioned above.CONCLUSION:P75NGFR participates in the developmental process of tooth germ and tooth tissues.

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Available abstract

AIM:To investigate the expression and localization of P75NGFR during mouse tooth germ development.METHODS:Immunohistochemical staining and image analysis technique were used to observe and analyze the expression of P75NGFR during mouse tooth germ development.RESULTS:P75NGFR was expressed at all stages of mouse tooth germ development with different degrees.The expression of P75NGFR was positive in oral epithelium and enamel organ epithelial cells at bud stage.P75NGFR was expressed positively in oral epithelium and stellate reticulum of cap stage and bell stage(E14 d～P1 d).During postnatal 2~10d(crown development stage);P75NGFR was found positive in ameloblast,odontoblast,predentin,dental papilla cells and dental sac cells.During P10~30d(tooth root development stage),P75NGFR was strongly positive in epithelial root sheath and alveolar bone besides those mentioned above.CONCLUSION:P75NGFR participates in the developmental process of tooth germ and tooth tissues.

Key concepts: Dental papilla, Germ, Enamel organ, Biology, Immunohistochemistry, Epithelium, Ameloblast, Dental alveolus

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Expression and localization of P75NGFR during mouse tooth germ development — Research Paper | ScholarLens