2003•Yati yasui yazhoubingxue zazhiRequires access

Expression and distribution of cyclooxygenase-2 in rat tooth germ development

Zhang Shao-feng

Abstract

AIM:To determine the expression and distribution of COX-2, and possible function in the rat tooth germ development.METHODS:Selected sections of every stage of developing rat molar teeth were prepared and stained immunohistochemically with polyclonal rabbit anticyclooxygenase-2 at a concentration of 1 ∶200.RESULTS: COX-2 had its own specific temporospatial pattern during tooth germ development. It was expressed focally in the oral epithelium, dental lamina, outer enamel epithelium, stratum intermedium and stellate reticulum at cap and bell stages. CONCLUSION:These data are the first to show the dynamic spatial and temporal distribution of expression of COX-2 during various stages of the rat tooth germ development and suggest that it contributes to the rat tooth germ development.

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Key concepts: Dental lamina, Germ, Epithelium, Molar, Biology, Cell biology, Pathology, Medicine