The Changes of Serum C-reactive Protein Level in Patients with Coronary Artery Disease and Its Clinical Significance

Objective: To study the changes of serum C-reactive protein (CRP) level in patients with coronary artery disease (CAD) and its clinical significance. Methods: CRP levels of 97 patients with CAD diagnosed by using coronary angiography, and 28 people without the disease (control group) were measured with automatic biochemical analysator. All the CAD patients were divided into subgroups of acute coronary syndrome (ACS) and non-acute coronary syndrome (NACS), and into subgroups of one diseased vessel (subgroup 1), two diseased vessels (subgroup 2), and three diseased vessels (subgroup 3). The data were analyzed. Results: (1) CRP in patients with CAD was significantly higher than that of control group (P0.05); (2) CRP in patients with ACS and without ACS was significantly higher than that of control group (P0.05), also, CRP in patients with ACS was significantly higher that of patients in subgroup NACS, (P0.05); (3) CRP in patients of subgroup 1, 2, and 3 was significantly higher than that of people of control group (P0.05); CRP in patients of subgroups 2 and 3 was higher than that of subgroup 1 (P0.05), and that of subgroup 3 was higher than that of subgroup 2 (P0.05). Conclusions: (1) CRP may be correlated with CAD; (2) The increase of CRP level may reflect the instability of coronary artery plaque and the severity of CAD.