Comparison of serum total bile acid and conventional indicators of liver enzymes in the disease in liver and gallbladder

Objective To investigate the serum total bile acid(TBA) levels in liver cirrhosis,liver cancer and obstructive jaundice and the clinical value.Methods TBA level was tested in 120 patients with liver and gallbladder disease(case group) and 80 healthy subjects(control group) testing with enzymatic cycling method.The activity of traditional indicators of liver enzyme alanine aminotransferase(ALT),aspartate acid aminotransferase(AST),alkaline phosphatase(ALP),and r glutamyl transferase(GGT) were also tested at the same time,with a comparative analysis of test results.Results Serum TBA level in patients with liver cirrhosis,liver cancer,and obstructive jaundice were significantly higher than that in the control group(P0.01).And the serum TBA level of patients with liver cirrhosis and obstructive jaundice group were significantly higher than that of patients with liver cancer(P0.01).The positive rates of serum TBA in patients with cirrhosis,liver cancer and obstructive jaundice were 100%,80%,and 100% respectively.And all were significantly higher than the traditional indicators of liver function enzymes(P0.01).Conclusion TBA can reflect liver cell injury,and it is a good indicator of biliary obstruction,with sensitivity and specificity,superior to conventional liver enzyme test items for the early diagnosis of liver and gallbladder diseases.It has important clinical value for disease surveillance.