Expression and correlation of CD147 protein and apoptosis inhibiting gene Survivin in bladder cancer

Objective To investigate the expression and relationship of CD147 protein and apoptosis inhibiting gene Survivin in bladder cancer. Methods CD147 protein and apoptosis inhibiting gene Survivin were detected in 42 cases of bladder cancer tissues and 24 cases normal bladder tissues,from 2012 January to 2014 June in our hospital operation treatment,RT-PCR was used to detect the expression of Survivin mRNA in bladder cancer tissue and normal bladder tissue,immunohistochemical SP method was used to detect the expression of CD147 protein in bladder carcinoma and normal bladder tissues,the results were analysed statistically. Results No Survivin gene expression in normal bladder tissue,expression rate of Survivin gene in bladder cancer was 76.19%,the positive rate of CD147 expression was 4.17%in the normal bladder tissue,the positive rate of CD147 expression was 78.57%in bladder cancer tissues;42cases of patients with bladder cancer CD147 protein and Survivin gene expression were positive in 31 cases,double positive expression rate was 73.81%,double negative expression rate of 19.04%.The Spearman correlation analysis,significant positive correlation between CD147 protein and Survivin gene in bladder cancer(r=0.798,P0.05);CD147protein and Survivin gene expression in bladder cancer tissue positively correlated with the TNM staging(P0.05).Conclusions Protein CD147 and apoptosis suppressor gene Survivin has higher expression of its expression is closely related to both,abnormal expression of Survivin gene and protein CD147 upregulation may play a synergistic role in the development of bladder cancer.