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2007•Journal of Clinical UrologyRequires access

Expression of survivin mRNA and its clinical implications in bladder cancer

DI Jinming

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Abstract

Objective:To investigate the expression of survivin mRNA in carcinoma of bladder and it's clinical implications.Methods:Expression of survivin mRNA was detected by RT-PCR, and it's relations with the clinicopathologic parameters in bladder cancer was analyzed.Results:The total rate of survivin mRNA expression in patients with bladder carcinoma was 78.6%(33/42). The expression rate of survivin mRNA in infiltrated tumor (95.%)(22/23) was significantly higher than that in superficial bladder cancer (57.9%)(11/19), and the expression rate of survivin mRNA in relapsed tumors (95.0%)(19/20) was much higher than that in initial bladder cancers (63.6%)(14/22)(P0.05). Survivin mRNA was not detected in normal mucosa of bladder in the control group.Conclusions:As a sensitive biomarker for bladder cancer, the expression of survivin mRNA can serve as an indicator to predict recurrence and infiltration in bladder cancer.

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Objective:To investigate the expression of survivin mRNA in carcinoma of bladder and it's clinical implications.Methods:Expression of survivin mRNA was detected by RT-PCR, and it's relations with the clinicopathologic parameters in bladder cancer was analyzed.Results:The total rate of survivin mRNA expression in patients with bladder carcinoma was 78.6%(33/42). The expression rate of survivin mRNA in infiltrated tumor (95.%)(22/23) was significantly higher than that in superficial bladder cancer (57.9%)(11/19), and the expression rate of survivin mRNA in relapsed tumors (95.0%)(19/20) was much higher than that in initial bladder cancers (63.6%)(14/22)(P0.05). Survivin mRNA was not detected in normal mucosa of bladder in the control group.Conclusions:As a sensitive biomarker for bladder cancer, the expression of survivin mRNA can serve as an indicator to predict recurrence and infiltration in bladder cancer.

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Available abstract

Objective:To investigate the expression of survivin mRNA in carcinoma of bladder and it's clinical implications.Methods:Expression of survivin mRNA was detected by RT-PCR, and it's relations with the clinicopathologic parameters in bladder cancer was analyzed.Results:The total rate of survivin mRNA expression in patients with bladder carcinoma was 78.6%(33/42). The expression rate of survivin mRNA in infiltrated tumor (95.%)(22/23) was significantly higher than that in superficial bladder cancer (57.9%)(11/19), and the expression rate of survivin mRNA in relapsed tumors (95.0%)(19/20) was much higher than that in initial bladder cancers (63.6%)(14/22)(P0.05). Survivin mRNA was not detected in normal mucosa of bladder in the control group.Conclusions:As a sensitive biomarker for bladder cancer, the expression of survivin mRNA can serve as an indicator to predict recurrence and infiltration in bladder cancer.

Key concepts: Survivin, Bladder cancer, Medicine, Messenger RNA, Clinical significance, Cancer research, Oncology, Infiltration (HVAC)

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