The Study of P-glycoprotein and Survivin, Fas Expression and Their Correlation in Bladder Transitional Cell Carcinoma

Objective: To explore the relationship of expression among P- glycoprotein (P-GP), Survivin, Fas and their correlation with the biologic behavior of bladder transitional cell carcinoma(BTCC). Methods: Immunohistochemistry was used to detect the expression of P-GP, Survivin , Fas in BTCC(n = 64) and normal bladder mucosa(n = 12). Results: The positive expression rate of Survivin and P-GP in BTCC was higher than normal bladder mucosa and strongly correlated with clinical grading (P 0.01); the Fas expression in the normal bladder mucosa was higher than those in the BTCC and the difference was statistical(P 0.01). The positive P-GP expression rate of recurrent BTCC was higher than primary BTCC(P 0.01). The expression of Survivin and P-GP in BTCC had negative correlation with Fas expression but the Survivin and P-GP expression had no correlation. Conclusion: The multidrug resistence(MDR) P-GP of BTCC is strongly correlated with the expression of Fas but not correlated with the Survivin expression .It may provide evidence to increase the chemotherapy sensitivity of BTCC by using MDR reverse agents or Fas interference.