Expression of Survivin and Caspase-3 in Bladder Transitional Carcinoma and Their Significance

Objective To investigate the expressions of survivin and caspase-3 and evaluate their effects on the tumorigenesis and progression in bladder transitional carcinoma(BTCC).Methods The immunohistochemistry (SP method) was used to determine the expression of survivin and caspase-3 in 60 cases of BTCC and 10 normal bladder mucosas.Results The protein expression levels of survivin(63.3%) in BTCC was significantly higher than those in normal bladder samples(20.0%),and the levels was correlated with grades of BTCC.But the expression of caspase-3 in BTCC(53.3%) was significantly lower than those in normal bladder samples(90%),and its expression level was also related to the grade of BTCC.A significant correlation between survivin and caspase-3 gene expression in bladder transitional cell cancer was found.There is negative relationship between survivin and caspase-3 expression in bladder transitional cell cancer.Conclusion Both over expression of survivin and descended expression of caspase-3 may play an important role in the tumorigenesis and apoptotic regulation of bladder tissues.