Expressions of pituitary tumor transforming gene and P53 in colorectal carcinoma

Objective To investigate the expressions of pituitary tumor transforming gene(PTTG) and P53 in colorectal carcinoma and evaluate their clinical significance.MethodsSpecimens from colorectal carcinoma(60 cases) and normal colorectal tissues(20 cases) were analyzed by tissue microarray and immunohistochemical detection for PTTG and P53 expressions.ResultsThe positive rates of PTTG and P53 were 75.0% and 61.7%,respectively in colorectal carcinoma.The positive rates and expression grades in colorectal cancer tissues were significantly higher than that in normal colorectal tissues(P0.01).The expression of PTTG was correlated with lymph node metastasis,tumor diameter,and depth of infiltration of colorectal carcinoma(P,and P0.05).The expression grade of P53 was not correlated with differentiation,tumor diameter,and depth of infiltration of colorectal carcinoma(P0.05),however it was associated with lymph node metastasis(P0.05).The expression of PTTG was positively correlated with the expression of P53(r=0.495,P).ConclusionThe expressions of PTTG and P53 are associated with the progression and metastasis of colorectal carcinoma,and PTTG and P53 may be used as molecular markers for judging the metastasis potential and the invasion of colorectal carcinoma.