Expression of pituitary tumor transforming gene and P53 in colorectal cancer

Objective To investigate the expression of pituitary tumor transforming gene(PTTG)and P53 in colorectal cancerpatients and the relationship between levels of PTTG and and P53 and progression and metastasis of colorectal cancer Methods Immunochemical staining was performed to detect the expression of PTTG and P53 in 42 colorectal cancer tissues and 42 normal control tissues.Results The positive rate of PTTG,and P53 were 88.1% and 95.2% in colorectal cancer tissues.The positive rate and expression grade in colorectal cancer tissues were significantly higher than that in normal control tissues(P0.01),No relationship between expression of PTTG and tumor typing or differentiation colorectal cancer(P0.05).but the expression of PTTG in metastasis group was much higher than the negative group(P0.05).No relationship between expression of P53 and tumor typing,metastasis or differentiattion of colorectal cancer was observed(P0.05).Conclusion The expression of PTTG,is associated with the progression and metastasis of colorectal cancer,and PTTG,may be used as molecular markers for judging the metastasis potential and the prognosis of colorectal cancer.