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2013•Journal of Jinggangshan UniversityRequires access

RESEARCH ON BAICALIN SOLID DISPERSION

Ma Shan-Shan

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Abstract

Objective : To prepare and investigate baicalin solid dispersion. Methods: Using PEG6000 as carrier, baicalin solid dispersion was prepared by solvent, melting, solvent-melting, grinding methods. The influence on solid dispersion of different proportion was studied by UV, IR, solubility and dissolution rate. Results: The solid dispersions of solvent method and the ratio of the drug and PEG6000 1:8 is the best. Conclusion: The quality of solid dispersion was affected by the preparation method and the ratio.

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What this paper is about

Objective : To prepare and investigate baicalin solid dispersion. Methods: Using PEG6000 as carrier, baicalin solid dispersion was prepared by solvent, melting, solvent-melting, grinding methods. The influence on solid dispersion of different proportion was studied by UV, IR, solubility and dissolution rate. Results: The solid dispersions of solvent method and the ratio of the drug and PEG6000 1:8 is the best. Conclusion: The quality of solid dispersion was affected by the preparation method and the ratio.

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Available abstract

Objective : To prepare and investigate baicalin solid dispersion. Methods: Using PEG6000 as carrier, baicalin solid dispersion was prepared by solvent, melting, solvent-melting, grinding methods. The influence on solid dispersion of different proportion was studied by UV, IR, solubility and dissolution rate. Results: The solid dispersions of solvent method and the ratio of the drug and PEG6000 1:8 is the best. Conclusion: The quality of solid dispersion was affected by the preparation method and the ratio.

Key concepts: Baicalin, Dispersion (optics), Dissolution, Solvent, Solubility, Materials science, Grinding, Chromatography

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