2010•Shanxi Yike Daxue xuebaoRequires access

Study on the solid dispersion of baicalin-PVP_(K30)

Qin Xue-mei

Abstract

Objective To prepare a baicalin-PVPK30 solid dispersion for increasing the solubility property of baicalin. Methods Taking PVPK30 as a carrier,solid dispersions of baicalin were prepared by solvent evaporation method. The influence of PVPK30 dosage on the solubility and dissolution of baicalin was evaluated. The solid dispersions were identified by infrared spectroscopy ( IR) ,differential scanning calorimetry ( DSC) and X-ray diffraction analysis ( XRD) . Results The optimal weight ratio of baicalin and matrix PVPK30 was 1∶ 5. The identification test showed that the solid dispersion of baicalin-PVPK30 existed in an amorphous form of solid dispersion system. Solubility of baicalin-PVPK30( 1∶ 5) was ( 305. 4 ± 1. 33) μg/ml,while the solubility of baicalin was ( 58. 12 ± 5. 53) μg/ml. The dissolution of baicalin-PVPK30( 1∶ 5) was more than 70% in 60 min,while raw material medicine was dissolved only 25% . Conclusion The results suggest that the solid dispersion could apparently increase the solubility and dissolution of baicalin.

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Key concepts: Baicalin, Solubility, Dissolution, Differential scanning calorimetry, Dispersion (optics), Solvent, Chemistry, Amorphous solid