Study on the preparation and dissolution in vitro of baicalin solid dispersion

OBJECTIVE To improve the dissolution rate of baicalin by the way of preparing baicalin solid dispersions,and investigate the effect of Tween-80 on the dissolution of baicalin in solid dispersions.METHODS The solid dispersions in different ratio of two kinds of carriers(PEG 6000 and PVP K30) were made by solvent method or melting method.The dissolution characteristics of baicalin,physical mixtures and solid dispersions were compared,in order to get the best carrier and ratio,and then add different ratio of Tween-80 in solid dispersion in order to investigate the effect of Tween-80 on the dissolution.RESULTS The solid dispersions of baicalin by using PVP as a carrier had quicker and higher dissolution than those using PEG as a carrier.With the increase of the dosage of Tween-80 in PVP solid dispersions,the dissolution of baicalin was significantly faster and higher.CONCLUSION The PVP solid dispersion in the ratio of 1∶8(baicalin∶PVP) which prepared by solvent method can improve the dissolution rate of baicalin significantly.Tween-80 can further enhance the drug dissolution in solid dispersions.