2010•Pharmacy and Clinics of Chinese Materia MedicaRequires access

Effects of modified Sanjia Powder and Its sub-formulas on the PIIINP and HA of rats with hepatic fibrosis

Ying Yan

Abstract

Objective:To partly clarify the mechanism of modified Sanjia Powder and its Sub-Formulas on hepatic fibrosis by observing the effects on N-terminal Procollagen Ⅲ Propeptide(PⅢNP) and Hyaluronic Acid(HA) of rats with hepatic fibrosis.Method:The hepatic fibrosis model in rats was established by CCl4 administration.And the concentration of PⅢNP and HA in serum were tested.Result:The group of modified Sanjia Powder can decrease the level of PⅢNP and HA(P0.01),and the group without Yin-enriching material can lower the level of HA(P0.05) compared with blank group.Conclusion:Modified Sanjia Powder and its sub-formulas have the effects on experimental hepatic fibrosis by promoting collagen-degradation.

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Key concepts: Hepatic fibrosis, Procollagen peptidase, Hyaluronic acid, Fibrosis, CCL4, Internal medicine, Medicine, Gastroenterology