Effects of Xiaodan granules on chronic renal function failure rats induced by adenine

Objective To observe the effects of Xiaodan granules on renal function of rats with chronic renal failure(CRF)induced by adenine. Methods Except for the normal control(n=10),the rats with CRF induced by adenine were randomly divivded into five groups:model,low,middle,high-dosage(0.989,1.977,3.956 g / kg·d) of Xiaodan granules and positive control group with Niaoduqing granules(2.088 g / kg·d),n =12,for each group.Corresponding drugs were given to these five groups for 30 days,The serum creatinine(SCr),blood urea nitrogen(BUN),uric acid(UA),and electrolyte K+,Na+,Ca2 +,P3 +,as well as proteinuria(PRO),neutrophils(LEU),urine specific gravity(SG),and renal pathology were observed and compared each other to find out differences among them. Results Compared with the model group,SCr,BUN,UA and P3 +of other 5 groups were significantly decreased,and the index of PRO,LEU,SG tended to be normal. Conclusion Xiaodan granules have definitely therapeutic effect on chronic renal failure of rats caused by adenine.