Protective Effects of Xiaodan Granules on Renal Function of Rats with Chronic Renal Failure Induced by Adenine

OBJECTIVE:To study the protective effects of Xiaodan granules on renal function of rats with chronic renal failure(CRF)induced by adenine. METHORDS:60 Wistar rats were randomly divided into normal control group(constant volume of normal saline),model group(constant volume of normal saline),Niaoduqing granules group(2.088 g/kg)and Xiaodan granules high-dose,medium-dose and low-dose groups(3.956,1.977,0.989 g/kg). They were given relevant medicines intragastrically,once a day,for consecutive 30 days. The renal failure model of rats was induced by intragastric administration of adenine(200 mg/kg),once a day,for consecutive 30 days. The serum creatinine(Scr),blood urea nitrogen(BUN),uric acid(UA),electrolyte K+,Na+,Ca2+,P3+,proteinuria(PRO),neutrophils(LEU)and urine specific gravity(SG)were determined,and renal pathology was observed under light microscope. RESULTS:Compared with normal control group,the serum contents of Scr,BUN,UA and P3+,and the contents of PRO and LEU in urine were increased in model group,while SG level was decreased;there was statistical significance(P0.01). Renal tissue of rats was gray white,and intraglomerular mesangial region broadened significantly. The intraglomerular mesangial matrix increased significantly,and a large number of inflammatory cell infiltration and thickening of blood vessels were found in renal tubules and interstitium. Compared with model group,the serum contents of Scr,BUN,UA and P3+,the contents of PRO and LEU in urine were decreased in Xiaodan granules high-dose,medium-dose and low-dose groups,while SG level was increased;there was statistical significance(P0.01,P0.05). The symptom of renal pathology had been improved to certain extent. CONCLUSIONS:Xiaodan granules have definitely therapeutic effect on chronic renal failure of rats caused by adenine.