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2013•The Chinese Journal of Clinical PharmacologyRequires access

Experimental study of effect of Xiaodan Granules on renal function of rats with chronic renal failure

Yanxi Wang

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Abstract

Objective To explore the effect of Xiaodan Granules on renal function of rats with chronic renal failure(CRF) induced by adenine.Methods Except for the normal group,the rats with CRF induced by adenine were randomly divivded into five groups: model group,low,mediate,high dosage(0.99,1.98,3.96 g ·kg-1) of Xiaodan Granules group and positive control group with Niaoduqing Granules(2.09 g · kg-1).Corresponding drugs were given to these five groups for 30 days.The serum creatinine(SCr),blood urea nitrogen(BUN) and pathology were investigated to find out differences among them.Results Compared with the model group,SCr and BUN in Xiaodan Granales and Niaoduqing Grahules groups were significantly decreased,and renal pathology have improved in all treated CRF rats.Conclusion Xiaodan Granules have definitely therapeutic effect on chronic renal failure of rats caused by adenine.

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What this paper is about

Objective To explore the effect of Xiaodan Granules on renal function of rats with chronic renal failure(CRF) induced by adenine.Methods Except for the normal group,the rats with CRF induced by adenine were randomly divivded into five groups: model group,low,mediate,high dosage(0.99,1.98,3.96 g ·kg-1) of Xiaodan Granules group and positive control group with Niaoduqing Granules(2.09 g · kg-1).Corresponding drugs were given to these five groups for 30 days.The serum creatinine(SCr),blood urea nitrogen(BUN) and pathology were investigated to find out differences among them.Results Compared with the model group,SCr and BUN in Xiaodan Granales and Niaoduqing Grahules groups were significantly decreased,and renal pathology have improved in all treated CRF rats.Conclusion Xiaodan Granules have definitely therapeutic effect on chronic renal failure of rats caused by adenine.

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Available abstract

Objective To explore the effect of Xiaodan Granules on renal function of rats with chronic renal failure(CRF) induced by adenine.Methods Except for the normal group,the rats with CRF induced by adenine were randomly divivded into five groups: model group,low,mediate,high dosage(0.99,1.98,3.96 g ·kg-1) of Xiaodan Granules group and positive control group with Niaoduqing Granules(2.09 g · kg-1).Corresponding drugs were given to these five groups for 30 days.The serum creatinine(SCr),blood urea nitrogen(BUN) and pathology were investigated to find out differences among them.Results Compared with the model group,SCr and BUN in Xiaodan Granales and Niaoduqing Grahules groups were significantly decreased,and renal pathology have improved in all treated CRF rats.Conclusion Xiaodan Granules have definitely therapeutic effect on chronic renal failure of rats caused by adenine.

Key concepts: Chronic renal failure, Blood urea nitrogen, Creatinine, Renal function, Internal medicine, Medicine, Normal group, Endocrinology

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