Clinical Study of Edaravone for Treatment on Acute Massive Cerebral Infarction

Objective To investigate the efficacy and mechanism of Edaravone for treatment on acute massive cerebral infarction.Methods Totally 62 patients with acute massive cerebral infarc-tion were randomly divided into Edaravone group(32 cases) and control group(30 cases);and were treated with conventional therapy.Edaravone group patients were admitted with Edaravone 30 mg,twice a dayt,wo weeks.Neurologic function deficit scores(NDS),Barthel index(BI) a,ctivity of super-oxide dismutase(SOD) l,ipid peroxide(LPO) were detected pre and post treatment.The efficacy was compared between the two grups.Results The NDS of two groups were significantly lower than those before treatment,BI was increasedt,he level of serum SOD was increasedt,he levels of serum LPO was decreased in the two groups.Compared with those pre treatmentt,he changes of all the targets were sig-nificantly different(all P 0.01) a,nd Edaravone group improvement were obviously better than control group(all P 0.01).The total effective rate in Edaravone group(87.5%) was significantly higher than that in control group(66.6%)(P 0.01).Conclusion Treatment with Edaravone for acute massive cerebral infarction is effectual.