Curative effects observatin of Edaravone on the patients with acute massive cerebral infarction

Objective To observe the curative effects of treatment with Edaravone for acute massive cerebral infarction.Methods 48 patients with acute massive cerebral infarction were randomized into the treatment with Edaravone group(Edaravone group,24 patients) and the conventional treatment control group(control group,24 patients).Two groups patients were admitted conventional treatment for cerebral infarction.Edaravone group patients were admitted with Edaravone 30 mg into 100 ml saline infusion introvenously,twice a day,linked 20 ～ 25 d.Respectively before and after the treatment,neurologic function dificit score(NDS),plasma fibrinogen(Fib) content,coagulation blood function,activity of superoxide dismutase(SOD) were examined.The clinical efficacy was compared between the two groups.Results NDS of tow groups after treatment were significantly lower than those of before treatment,activity of SOD were significantly increased than those before treatment(all P0.05).Edaravone group improvement were obviously better than those in the control group(all P0.05).Plasma Fib contents and coagulation blood function in the two groups before and after treatment were no statistically significant difference(all P0.05).Significant efficiency ratio of the Edaravone group(87.5%) was significantly higher than that of the control group(45.8%)(P0.05).In the Edaravone group,there were 2 cases in liver transaminases mildly elevated,4 cases in blood urea nitrogen elevated.After corresponding treatment,these cases were back to normal in the short term.Conclusion Treatment with Edaravone for acute massive cerebral infarction is effectual,no obvious adverse reactions.