Effect of edaravone on the serum levels of TNF-α and IL-8 in patients with cerebral infarction

AIM: To explore the effect of edaravone on the serum levels of TNF-α and IL-8 in patients with cerebral infarction. METHODS: A total of 82 cases with cerebral infarction were divided randomly into control group (40 cases) and edaravone group (42 cases). All cases were given routine treatment,and the edaravone group were added with edaravone 30 mg,twice daily for 14 d IVGTT. The serum levels of TNF-α and IL-8 and clinical outcome were investigated before and 15 d after treatment. RESULTS: The therapeutic efficacy (86.49%) of edaravone group 15 d after treatment was significantly better than that of control group (62.86%,P0.01),and the serum levels of TNF-α and IL-8 in the edaravone group were lower than those of control group TNF-α (ng/L) 6.3±1.3 vs 10.2±3.0,IL-8 (ng/L) 10.2±3.0 vs 100.3±34.5,P0.01. CONCLUSION: Edaravone can reduce the injury of ischemic brain and improve therapeutic efficacy,probably by inhibiting the production of TNF-α and IL-8 and stopping the leukocytes from infiltrating into ischemic region.