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2010•Journal of Baotou Medical CollegeRequires access

The Relationship between G10631A Polymorphism in the Renin Gene and Cerebral Infarction

Yang Guo-an

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Abstract

Objective: To investigate the relationship between G10631A polymorphism in the renin gene and cerebral infarction.Methods: The polymorphism was genotyped among 82 cases and 89 controls by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results: The frequencies of AA genotype and A allele in cases were significantly higher than in controls(P0.05).Conclusion: The AA genotype and A allele of G10631A polymorphism in the renin gene might be susceptibility factors for cerebral infarction.

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What this paper is about

Objective: To investigate the relationship between G10631A polymorphism in the renin gene and cerebral infarction.Methods: The polymorphism was genotyped among 82 cases and 89 controls by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results: The frequencies of AA genotype and A allele in cases were significantly higher than in controls(P0.05).Conclusion: The AA genotype and A allele of G10631A polymorphism in the renin gene might be susceptibility factors for cerebral infarction.

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Available abstract

Objective: To investigate the relationship between G10631A polymorphism in the renin gene and cerebral infarction.Methods: The polymorphism was genotyped among 82 cases and 89 controls by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results: The frequencies of AA genotype and A allele in cases were significantly higher than in controls(P0.05).Conclusion: The AA genotype and A allele of G10631A polymorphism in the renin gene might be susceptibility factors for cerebral infarction.

Key concepts: Genotype, Cerebral infarction, Allele, Restriction fragment length polymorphism, Polymorphism (computer science), Polymerase chain reaction, Gene polymorphism, Gene

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